The impact of tardive dyskinesia (TD) goes far beyond involuntary movements1,2

75% of patients reported that TD severely impacted them socially, physically, and psychologically3


3-year longitudinal registry and study ongoing to assess the impact of TD and real-world treatment patterns and outcomes: learn more The Phase 4, multicenter, prospective, observational 2-part study is the largest ever of its kind for TD and will collect information from both patients and physicians.

In a survey of 269 patients, the impact of TD on daily living was substantial—even for patients with self-assessed mild/moderate symptoms4

Psychological/psychiatric factors3

  • Effect on underlying condition
  • Compliance with treatment
  • Development of other psychiatric symptoms (eg, anxiety)
  • Other negative emotions

Social factors2,5

  • Effect on relationships
  • Social isolation
  • Withdrawal

Physical factors2,6,7

  • Speech impairment
  • Difficulty eating
  • Reduced fine motor function
  • Impaired gait/balance

Vocational factors8

  • Inability or reduced ability to perform job duties
  • Challenges with employment
  • Avoidance of people

TD symptoms can disrupt the treatment of your patient’s underlying condition4,8

In the same survey, patients with TD reported that their involuntary movements interfered with adherence to psychiatric treatment4:

48.4%

Skipped doses of antipsychotic medication or took less than doctor instructed

39.3%

Stopped taking antipsychotic medication altogether

35.7%

Stopped going to the doctor to treat their underlying condition

20.8%

Advised someone else not to take an antipsychotic medication

Patient characteristics in the TD Impact study
  • Survey included patients with major depressive disorder, schizophrenia or schizoaffective disorder, and bipolar disorder4
  • Patients’ TD symptoms ranged from mild to very severe4
  • Patient population spanned a diverse range of races/ethnicities4
LEARN MORE: EVALUATING TD IMPACT

No clinical trials have been conducted to demonstrate that treating TD affects the outcomes presented on this page.

Watch Amber Hoberg, PMHNP-BC, discuss the importance of assessing and managing TD

Voiceover:

Welcome to TD Talks and today’s installment: The need to assess and manage tardive dyskinesia, or TD.


Amber Hoberg:

Hi, I’m Amber Hoberg. I’ve been a psychiatric nurse practitioner treating people with TD for more than 10 years.


As a known complication of antipsychotic drugs, TD affects about 500,000 patients in the United States.


Yet, many of these patients may not tell us about their symptoms or may minimize the impact that TD is having on their lives. It’s therefore critical that we do not make assumptions and do everything we can to uncover the true impact of TD. That way, we can ensure that patients receive the quality care they need.


So, if patients aren’t complaining about their TD symptoms, why are they still so important to assess and manage?


TD can have a profound impact on everyday life for these patients, including the way it affects their primary condition and treatment with antipsychotic drugs, or APDs. This often manifests in the cycle you see here.


Patients with TD can experience a significantly more severe and refractory course of their primary condition. This can include a poor response to care and an increased risk of relapse or readmission.


In addition, patients have said that involuntary movements affect their physical health and can make everyday activities a challenge.


Despite this, between 20 and 30 percent of patients may not be aware that they are experiencing TD symptoms. It is for these very important reasons that we need to be sure we’re assessing our patients for TD—even if they’re not bringing up the subject themselves.


Whether minor or very apparent, the symptoms of TD can affect every patient, and those who care for them, differently. That is why it is so important not only to talk to the patient, but to also involve the patient’s family or caregivers in your assessment.


For example, I often engage a patient’s spouse or partner to see the impact the symptoms might be having on their everyday lives and relationships at home.


We can start by asking about symptoms across these 3 categories: psychosocial, functional, and physical. These questions can help identify the presence of TD and evaluate the severity of each patient’s symptoms.


To see TD symptoms more clearly, you can ask your patient to perform activation maneuvers, as shown onscreen. Activation maneuvers can help reveal any underlying TD symptoms or highlight symptoms that may initially be less apparent. If any involuntary movements are noted, a thorough workup should be done.


Although asking patients about the impact of symptoms on their life is the first step in our evaluation, it is also important to consider the objective severity of TD symptoms and how they may affect functioning.


Therefore, it is best practice to also use standardized measures such as the AIMS scale. By using the AIMS scale, we have a consistent way to evaluate patients’ TD symptoms and response to management over time.


Remember, it is not just the more severe scores that require further evaluation—any score above zero should trigger a deeper qualitative assessment on how those functions may be affecting their daily life.


AIMS can be performed in both in-person or telehealth settings. However, virtual assessments should be intermixed with live exams when possible.


The APA recommends clinical assessment of abnormal involuntary movements prior to initiating APD therapy and at follow-up visits. The exact frequency of AIMS follow-up is driven by APD history and level of risk.


If assessments are scheduled virtually, there are a few considerations to keep in mind.


Be sure to work out the appropriate camera angle with your patient prior to initiating the exam. I recommend activating your patients by mimicking their maneuvers on your end of the screen—so make sure they can see you, too.


If you cannot see your patient clearly onscreen, you may need to rely on patient commentary or a caregiver’s observation to evaluate certain body locations. If the platform doesn’t work at all, request to switch to a different program so you’re able to view your patient more clearly.


As rigidity cannot be formally assessed remotely, observe the arms while the patient is walking. Absence of arm swing can be a clinical sign of rigidity.


Lastly, be aware of the limitations that may be encountered during the assessment, including the inability to observe lower limbs, midline structures, and upper limbs. Inability to assess rigidity associated with parkinsonism; and technological limitations that may affect the test.


In summary, it’s critical to identify and address TD in order to minimize the effects that it can have on patients’ well-being.


Do so by leveraging established assessment criteria, and ask further questions to reveal the true impact that their symptoms may be having on their life.


Remember, by assessing the impact of TD and managing symptoms, you can make a tremendous difference in a patient’s life.


Thanks for watching this installment of TD Talks.

REFERENCES: 1. Cloud LJ, Zutshi D, Factor SA. Tardive dyskinesia: therapeutic options for an increasingly common disorder. Neurotherapeutics. 2014;11(1):166-176. 2. Yassa R. Functional impairment in tardive dyskinesia: medical and psychosocial dimensions. Acta Psychiatr Scand. 1989;80(1):64-67. 3. Data on file. Parsippany, NJ: Teva Neuroscience, Inc. 4. Jain R, Ayyagari R, King S, Edwards GG, Wilhelm A, Leo S. Impact of tardive dyskinesia on physical, psychological, and social aspects of patient lives: a survey of patients and caregivers in the United States. Poster presented at: Psych Congress 2021; October 29–November 1, 2021; San Antonio, TX. 5. Ascher-Svanum H, Zhu B, Faries D, Peng X, Kinon BJ, Tohen M. Tardive dyskinesia and the 3-year course of schizophrenia: results from a large, prospective, naturalistic study. J Clin Psychiatry. 2008;69(10):1580-1588. 6. Strassnig M, Rosenfeld A, Harvey PD. Tardive dyskinesia: motor system impairments, cognition and everyday functioning. CNS Spectr. 2018;23(6):370-377. 7. Waln O, Jankovic J. An update on tardive dyskinesia: from phenomenology to treatment. Tremor Other Hyperkinet Mov (N Y). 2013;3:tre-03-161-4138-1. 8. Jackson R, Brams MN, Citrome L, et al. Assessment of the impact of tardive dyskinesia in clinical practice: consensus panel recommendations. Neuropsychiatr Dis Treat. 2021;17:1589-1597.